Expertin

Dr Doris Riether

Boehringer Ingelheim Research & Development Award 2010

Discovery of a novel potent and selective HSD17B13 Inhibitor, BI-3231, a well-characterized Chemical Probe available for Open Science

Thamm, S., Willwacher, M., Aspnes, G., Bretschneider, T., Brown, N., Buschbom-Helmke, S., Fox, T., Gargano, E., Grabowski, D., Hoenke, C., Matera, D., Mueck, K., Peters, S., Reindl, S., Riether, D., Schmid, M., Tautermann, C., Teitelbaum, A., Trünkle, C., Veser, T., Winter, M., Wortmann, L.

J. Med. Chem. 2023, 66(4), 2832-2850

Synthesis of 2’-modified N6-methyladenosine phosphoramidites and their incorporation into siRNA

Rydzik, A., Riether, D., Gottschling, D.

Bioorg. Med. Chem. Lett. 81 (2023), 129126

Identification of Highly Selective Orexin 1 Receptor Antagonists Driven by Structure-Based Design

Lessel, U. et al., and Riether, D.

J. Chem. Inf. Model. 2021, 5893–5905

Access to 1′-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides

Rydzik, A.M., Balk, R., Koegler, M., Steinle, T., Riether, D., Gottschling, D.

Organic Letters, 2021, 6735–6739 and Cover

Epigenetic Modification 6-Methyladenosine Can Impact the Potency and Specificity of siRNA

Rydzik, A.M. et al, and Riether, D.

ChemBioChem, 2021, 491–495

Discovery and optimization of oxadiazole-based FLAP inhibitors

Bartolozzi, A., Abeywardane, A., Bosanac, T., Broadwater, J. A., Chen, Z., Hutzler, J. M., Huber, J. D.,  Nemoto, P., Olague, A., Riether, D., Simpson, T., Takahashi, H., Wu, L., Zhang, Y., Zindell, R.M.

Bioorg. Med. Chem. Lett. 2017, 4652–4659

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)

Takahashi, H., Riether, D. et al.

J. Med. Chem. 2015, 1669-1690

Selective CB2 receptor agonists. Part 3: The optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model

Bartolozzi, A. et al. and Riether, D.

Bioorg. Med. Chem. Lett. 2015, 587–592

Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds

Riether, D. et al.

Bioorg. Med. Chem. Lett. 2015, 581–586

Selective CB2 receptor agonists. Part 1: The identification of novel ligands through computer-aided drug design (CADD) approaches

Hickey, E.R. et al. and Riether, D.

Bioorg. Med. Chem. Lett. 2015, 575–580

Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate

C. Harcken, D. Riether et al.

ACS Med. Chem. Lett. 2014, 1318–1323

Discovery of a potent and dissociated non-steroidal glucocorticoid agonist containing an alkyl carbinol pharmacophore

H. Razavi, D. Riether et al.

Bioorg. Med. Chem. Lett. 2014, 1934–1940

Identification of Highly Efficacious Glucocorticoid Receptor Agonists with a Potential for Reduced Clinical Bone Side Effects

C.Harcken, D. Riether et al.

J. Med. Chem. 2014, 1583-1598

Selective cannabinoid receptor 2 modulators: a patent review 2009 – present

Riether, D.

Expert Opin. Ther. Patents 2012, 495-510

Aryl-1,4-diazepane compounds as potent and selective CB2 agonists: Optimization of drug-like properties and target independent parameters

Zindell, R., et al. and Riether, D.

Bioorg. Med. Chem. Lett. 2011, 4276-4280

Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability

Riether, D. et al.

Bioorg. Med. Chem. Lett. 2011, 2011-2016

Non-Steroidal Dissociated Glucocorticoid Agonists Containing Azaindoles as Steroid A-ring Mimetics

D. Riether et al.

J. Med. Chem. 2010, 6681-6698

Morpholine containing CB2 agonists

R. Zindell, D. Riether et al.

Bioorg. Med. Chem. Lett. 2009, 1604-1609

5-Aminomethylbenzimidazoles as Potent ITK Antagonists

D. Riether et al.

Bioorg. Med. Chem. Lett. 2009, 1588–1591

Arylsulfonamide CB2 Receptor Agonists: SAR and Optimization of CB2 Selectivity

M. Ermann, D. Riether et al.

Bioorg. Med. Chem. Lett. 2008, 1725-1729

A General and Efficient Synthesis of Azaindoles and Diazaindoles

C. Harcken, Y. Ward, D. Thomson, D. Riether

SYNLETT 2005, 3121-3125

Reactivity of Functional Groups on the Protein Surface: Development of Selective Probes for Protein Labeling

G. Chen, A. Heim, D. Riether et al.

Journal of the American Chemical Society 2003, 125, 8130-8133

Organic Procedures and Preparations International, Recent synthetic innovations for the preparation of cobyric acid

D. Riether & J. Mulzer

Eur. J. Org. Chem. 2003, 30-45

Highly efficient and stereoselective synthesis of the D-ring fragment of cobyric acid

J. Mulzer & D. Riether

Org. Lett. 2000, 2, 3139

Synthesis of the C-ring fragment of cobyric acid

J. Mulzer & D. Riether

Tet. Lett. 1999, 6197

Electrochemical Synthesis and Structure Analysis of Neocoenzyme B12

G. Kontaxis, D. Riether, R. Hannak, M. Tollinger and B. Kräutler

Helv. Chim. Acta 1999, 848-869