Expertin
Mag. Dr. Maria Waldhoer

Expertise

Naturwissenschaften: Molekulare Zellbiologie und Pharmakologie

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Ausbildung

Universität (1996)
Naturwissenschaften

Sprachen

  • Deutsch
  • Englisch
  • Dänisch
Mehr Details
  • Deutsch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Englisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Dänisch

    Schriftlich: Gute Kenntnisse
    Konversation: Verhandlungssicher / Fließend

Referenzen

Auszeichnungen / Preise

Sackler Preis (Salzburg) fuer Nachwuchswissenschafter fuer beste Dissertation

EMBO long term fellowship (2 Jahre) der European Molecular Biology Organization

2 FWF Schroedingerfellowships (not consumed)

Publikationen

Hohenegger M., Waldhoer M., Beindl W., Böing B., Kreimeyer A., Nickel P., Nanoff C. and M. Freissmuth (1998) Gs-selective G protein antagonists. Proc. Natl. Acad. Sci. USA, 95, 346-351.

Waldhoer M., Bofill-Cardona E., Milligan G., Freissmuth M. and C. Nanoff (1998) Differential uncoupling of A1-adenosine and D2-dopamine receptors by suramin and di-demethylated suramin (NF037), Molecular Pharmacology, 53, 808-818.

Waldhoer M., Wise A., Milligan G., Freissmuth M., and C. Nanoff (1999) Kinetics of ternary complex formation in fusion proteins composed of the A1-adenosine receptor and G protein  subunits, J. Biol. Chem., 274: 30571-30579.

Roka F., Brydon L., Waldhoer M., Strosberg A. D., Jockers R., Freissmuth M. and C. Nanoff (1999) Tight association of the human Mel1a-melatonin receptor and Gi: precoupling and constitutive activity, Molecular Pharmacology, 56: 1014-1024.

Kudlacek O*, Waldhoer M.*, Kassack M.U., Nickel P., Salmi J.A.I., Freissmuth M. and Nanoff C. (2002) Biased inhibition by a suramin analogue of A1-adenosine receptor/G protein coupling in fused receptor/G protein tandems: the A1-adenosine receptor is predominantly coupled to Go in human brain, Naunyn Schmiedebergs Arch Pharmacol., 365:8-16. * contributed equally to this work

Waldhoer M., Kledal TN, Helen Farrell, and Thue W. Schwartz (2002) Murine cytomegalovirus (CMV) M33 and human CMV US28 receptor exhibit similar constitutive signaling activity, Journal of Virology, 76: 8161-8

Fraile-Ramos A, Kohout TA, Waldhoer M., Marsh M. (2003) Endocytosis of the viral chemokines receptor US28 does not require beta-arrestins but is dependent on the clathrin-mediated pathway. Traffic, 4, 243-253.

Waldhoer M., Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. (2003) The carboxylterminus of human cytomegalovirus encoded 7TM receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol. Chem., 278:19473-82 [Epub ahead of print 2003 Mar 18].

Casarosa P., Waldhoer M., LiWang P. J., Vischer H., Kledal T.N., Timmerman H., Mokarski E.S., Schwartz T.W., Smit M.J., and Leurs R. (2005) CC and CX3C chemokines differentially interact with the N-terminus of the human cytomegalovirus-encoded US28 receptor. J. Biol. Chem, 280:3275-85 [Epub ahead of print 2004 Nov 16].

Kostenis, E., Martini L., Ellis J., Waldhoer M., Rosenkilde M., Norregaard P., Heydorn A., Jorgensen R., Whistler J.L., and Milligan G. (2004) A highly conserved glycine within linker I and the extreme C-terminus of G protein  subunits interact cooperatively in switching GPCR-to-effector specificity. J Pharmacol Exp Ther. [Epub ahead of print 2004 Dec 22]

Maria Waldhoer, Jamie Fong, Robert M. Jones, Mary M. Lunzer, Shiv K. Sharma, Evi Kostenis, Philip S. Portoghese, and Jennifer L. Whistler. (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers, Proc. Natl. Acad. Sci., in press (online 30 May 2005)

Reviews:
Freissmuth M., Waldhoer M., Bofill-Cardona E. and Nanoff C. (1999) G Protein Antagonists, Trends Pharmacol. Sciences, 20, 237-245.

Rosenkilde MM., Waldhoer M., Lüttichau H.-R- and Schwartz T.W. (2001) Virally encoded 7TM receptors Oncogene, 20, 1582-93.

Waldhoer M., Bartlett S. and Whistler J.L. (2004) Opioid receptors, Annual Reviews of Biochemistry, 73:953-90.

Maria Waldhoer
Mag. Dr. Maria Waldhoer

Ernest Gallo Clinic and Research Center

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Letzte Aktualisierung: 05.05.2023