Expertin

Assoc. Prof.in Enikö Kallay, Mag.a, Dr.in

Expertise

Humanmedizin: Erforschung molekularer Mechanismen der Kolonkrebsentstehung.

Schlagworte

Krebsforschung
Vitamin D
Kalzium
Molekulare Mechanismen
Epigenetik

Verfügbar für

Interviews

Jury

Kooperationen

Mentoring

Projektleitung

Projektmitarbeit

Vortragstätigkeiten

Beruflich

Mittleres Management

Tätigkeitsbereiche:

Universität

Ausbildung

Universität (1981)
Naturwissenschaften

Weitere Fachrichtungen, weitere Ausbildungen
Habilitation in experimentelle Pathophysiologie

Sprachen

Deutsch
Ungarisch
Rumänisch
Englisch

Mehr Details

Deutsch

Schriftlich: Verhandlungssicher / Fließend
Konversation: Muttersprache / wie Muttersprache
Ungarisch

Schriftlich: Muttersprache / wie Muttersprache
Konversation: Muttersprache / wie Muttersprache
Rumänisch

Schriftlich: Muttersprache / wie Muttersprache
Konversation: Muttersprache / wie Muttersprache
Englisch

Schriftlich: Verhandlungssicher / Fließend
Konversation: Muttersprache / wie Muttersprache

Referenzen

Auszeichnungen / Preise

Bristol-Myers Squibb Oncology Travel Award; at the Annual Meeting of the AACR, Washington D.C. 1996.
Poster award of the ASBMR. at the Int. Conference: Progress in Bone and Mineral Research, Vienna, 1998.
Int. Society for Preventive Oncology Travel Grant Award at the Int. Symposium on Predictive and Preventive Oncology, Nice, 1998.

Publikationen

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor. Iamartino L, Elajnaf T, Gall K, David J, Manhardt T, Heffeter P, Grusch M, Derdak S, Baumgartner-Parzer S, Schepelmann M, Kallay E. Biochim Biophys Acta Mol Cell Res. 2020 Dec;1867(12):118836. doi: 10.1016/j.bbamcr.2020.118836.
Cytomegalovirus Infection Downregulates Vitamin-D Receptor in Patients Undergoing Hematopoietic Stem Cell Transplantation. Robak O, Kastner MT, Stecher C, Schneider M, Andreas M, Greinix H, Kallay E, Honsig C, Steininger C. Transplantation. 2020 Sep 2. doi: 10.1097/TP.0000000000003448. Online ahead of print.
International Union of Basic and Clinical Pharmacology: Calcium-sensing receptor Nomenclature, Pharmacology, and Function” K. Leach, F. M Hannan, T. M Josephs, A. N Keller, T. C Møller, D. T Ward, E. Kallay, R. S Mason, R. V Thakker, D. Riccardi, A. D Conigrave, H. Bräuner-Osborne. Pharmacol Rev 72:1–48, July 2020, doi.org/10.1124/pr.119.018531, Review,
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice, Elajnaf T, Iamartino L, Mesteri I, Müller Ch, Bassetto M, Manhardt T, Baumgartner-Parzer S, Kallay E, Schepelmann M. Nutrients, 2019, 11 (12). DOI: 10.3390/nu11123072 Q1.
Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR). Chavez-Abiega S, Mos I, Centeno PP, Elajnaf T, Schlattl W, Ward DT, Goedhart J, Kallay E. Adv Exp Med Biol. 2020;1131:1031-1063. doi: 10.1007/978-3-030-12457-1_41. Review.
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model. Gröschel Ch, Prinz-Wohlgenannt M, Mesteri I, Karuthedom George S, Trawnicek L, Heiden D, Aggarwal A, Tennakoon S, Baumgartner M, Gasche Ch, Lang M, Marculescu R, Manhardt T, Schepelmann M, Kallay E. Nutrients, 2019, 12 (1). DOI: 10.3390/nu12010045.
The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. Nat Rev Endocrinol. 2018 Dec;15(1):33-51. doi: 10.1038/s41574-018-0115-0. Review.
Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives. Iamartino L, Elajnaf T, Kallay E, Schepelmann M. World J Gastroenterol. 2018 Sep 28;24(36):4119-4131. doi: 10.3748/wjg.v24.i36.4119. Review.
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK. Hegedüs L, Padányi R, Molnár J, Pászty K, Varga K, Kenessey I, Sárközy E, Wolf M, Grusch M, Hegyi Z, Homolya L, Aigner C, Garay T, Hegedüs B, Tímár J, Kállay E, Enyedi Á. Front Oncol. 2017 May 24;7:95. doi: 10.3389/fonc.2017.00095. eCollection 2017.
Expression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium. Aggarwal A, Schulz H, Manhardt T, Bilban M, Thakker RV, Kallay E. Biochim Biophys Acta. 2017 Jun; 1864(6):987-996. doi: 10.1016/j.bbamcr.2017.01.017.
The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells. Hegedũs L, Garay T, Molnár E, Varga K, Bilecz Á, Török S, Padányi R, Pászty K, Wolf M, Grusch M, Kállay E, Döme B, Berger W, Hegedũs B, Enyedi A. Int J Cancer. 2017 Jun 15;140(12):2758-2770. doi: 10.1002/ijc.30503. Epub 2016 Nov 17.
Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells. Rieder FJ, Gröschel C, Kastner MT, Kosulin K, Laengle J, Zadnikar R, Marculescu R, Schneider M, Lion T, Bergmann M, Kallay E, Steininger C. J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):356-362. doi: 10.1016/j.jsbmb.2016.08.002.
Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer. Aggarwal A, Kállay E. Front Physiol. 2016 Oct 18;7:451. Review. doi.org/10.3389/fphys.2016.0045.
The calcium-sensing receptor and the hallmarks of cancer. Tennakoon S, Aggarwal A, Kállay E. Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1398-407. doi: 10.1016/j.bbamcr.2015.11.017. Epub 2015 Nov 30. Review.
Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy. Höbaus J, Tennakoon S, Heffeter P, Groeschel C, Aggarwal A, Hummel DM, Thiem U, Marculescu R, Berger W, Kállay E. Int J Cancer. 2016; 138(2):440-50. doi: 10.1002/ijc.29717. Epub 2015 Aug 17.
The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E. Mol Cancer. 2015 Mar 18;14(1):61. doi: 10.1186/s12943-015-0330-4.
The link between obesity and vitamin D in bariatric patients with omega-loop gastric bypass surgery - a vitamin D supplementation trial to compare the efficacy of postoperative cholecalciferol loading (LOAD): study protocol for a randomized controlled trial. Luger M, Kruschitz R, Marculescu R, Haslacher H, Hoppichler F, Kállay E, Kienbacher C, Klammer C, Kral M, Langer F, Luger E, Prager G, Trauner M, Traussnigg S, Würger T, Schindler K, Ludvik B. Trials. 2015 Aug 5;16(1):328. doi: 10.1186/s13063-015-0877-9.
miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. Fetahu IS, Tennakoon S, Lines KE, Gröschel C, Aggarwal A, Mesteri I, Baumgartner-Parzer S, Mader RM, Thakker RV, Kállay E. Int J Cancer. 2015 Jul 14. doi: 10.1002/ijc.29681. [Epub ahead of print].
The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation: relevance to autosomal dominant hypocalcemia type 1 (ADH1). Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV. Endocrinology. 2015 Sep;156(9):3114-21. doi: 10.1210/en.2015-1269. Epub 2015 Jun 8.
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells. Gröschel C, Aggarwal A, Tennakoon S, Höbaus J, Prinz-Wohlgenannt M, Marian B, Heffeter P, Berger W, Kállay E. J Steroid Biochem Mol Biol. 2015 Mar 14. pii: S0960-0760(15)00049-7. doi: 10.1016/j.jsbmb.2015.02.011. [Epub ahead of print].
Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor. Aggarwal A, Höbaus J, Tennakoon S, Prinz-Wohlgenannt M, Graça J, Price SA, Heffeter P, Berger W, Baumgartner-Parzer S, Kállay E. J Steroid Biochem Mol Biol. 2015 Mar 7. pii: S0960-0760(15)00044-8. doi: 10.1016/j.jsbmb.2015.02.006. [Epub ahead of print].
The calcium-sensing receptor: A promising target for prevention of colorectal cancer. Aggarwal A, Prinz-Wohlgenannt M, Tennakoon S, Höbaus J, Boudot C, Mentaverri R, Brown EM, Baumgartner-Parzer S, Kállay E. Biochim Biophys Acta. 2015 Feb 18. pii: S0167-4889(15)00051-8. doi: 10.1016/j.bbamcr.2015.02.011. [Epub ahead of print].
The vitamin D system is deregulated in pancreatic diseases. Hummel D, Aggarwal A, Borka K, Bajna E, Kállay E, Horvath HC. J Steroid Biochem Mol Biol. 2014 2014 Oct;144 Pt B:402-9. doi: 10.1016/j.jsbmb.2014.07.011. Epub 2014 Jul 30.
Vitamin D and the epigenome. Fetahu IS, Höbaus J, Kállay E. Front Physiol. 2014 Apr 29;5:164. eCollection 2014. Review.
Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. Fetahu IS, Höbaus J, Aggarwal A, Hummel DM, Tennakoon S, Mesteri I, Baumgartner-Parzer S, Kállay E. Int J Cancer. 2014 Nov 1;135 (9):2014-23. doi: 10.1002/ijc.28856. Epub 2014 Apr 2.
Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells. Fetahu IS, Hummel DM, Manhardt T, Aggarwal A, Baumgartner-Parzer S, Kállay E. J Steroid Biochem Mol Biol. 2014;144PA:228-231. doi: 10.1016/j.jsbmb.2013.10.015. Epub 2013 Oct 28.
Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer cells. Hummel DM, Fetahu IS, Gröschel C, Manhardt T, Kállay E. J Steroid Biochem Mol Biol. 2014;144PA:91-95. doi: 10.1016/j.jsbmb.2013.09.017. Epub 2013 Oct 9.
"The role of the calcium sensing receptor (CaSR) in health and disease, implications for translational medicine" or the multifaceted CaSR: a Training Network for young scientists. Kállay E. Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):279-81. doi: 10.1016/j.beem.2013.05.004. Epub 2013 Jun 6.
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. Höbaus J, Hummel DM, Thiem U, Fetahu IS, Aggarwal A, Müllauer L, Heller G, Egger G, Mesteri I, Baumgartner-Parzer S, Kallay E. Int J Cancer. 2013 Sep 15;133(6):1380-8. Epub 2013 Apr 5.
Calcium sensing receptor signalling in physiology and cancer. Brennan SC, Thiem U, Roth S, Aggarwal A, Fetahu ISh, Tennakoon S, Gomes AR, Brandi ML, Bruggeman F, Mentaverri R, Riccardi D, Kallay E. Biochim Biophys Acta. 2013 Jul;1833(7):1732-44. Epub 2012 Dec 23.
Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases. Peterlik M, Kállay E, Cross HS. Nutrients. 2013 Jan 22;5(1):302-27.
Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases during Carcinogenesis. Höbaus J, Thiem U, Hummel DM, Kallay E. Anticancer Agents Med Chem. 2013;13(1):20-35.
Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis. Hummel DM, Thiem U, Höbaus J, Mesteri I, Gober L, Stremnitzer C, Graça J, Obermayer-Pietsch B, Kallay E. J Steroid Biochem Mol Biol. 2013;136:284-8.
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells. Höbaus J, Fetahu IS, Khorchide M, Manhardt T, Kallay E. J Steroid Biochem Mol Biol. 2013;136:296-9.
Colonic vitamin D metabolism: Implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Cross HS, Nittke T, Kallay E. Mol Cell Endocrinol. 2011, 5;347(1-2):70-9. Epub 2011 Jul 27.
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)2D3 in colorectal cancer. Horváth HC, Khabir Z, Nittke T, Gruber S, Speer G, Manhardt T, Bonner E, Kállay E. J Steroid Biochem Mol Biol. 2010, 121 (1-2), pp. 76-79.
The Candidate Oncogene CYP24A1: A Potential Biomarker for Colorectal Tumorigenesis. Horváth HC, Lakatos P, Kósa JP, Bácsi K, Borka K, Bises G, Nittke T, Hershberger PA, Speer G, Kállay E. J Histochem Cytochem. 2010;58(3):277-85.
Regulation of the colonic vitamin D system for prevention of tumor progression: an update. Cross HS, Kállay E. Future Oncol. 2009; 5(4):493-507.
Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Mostafaie N, Kállay E, Sauerzapf E, Bonner E, Kriwanek S, Cross HS, Huber KR, Krugluger W. Mol Carcinog. 2009, 48(7):642-7.
Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity. Protiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR. Cancer Prev Res (Phila Pa). 2009 Jan;2(1):43-51.
Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes Nittke T, Selig S, Kállay E and Cross H. S. Mol. Nutr. Food Res. 2008, 52, S45 –S51.
Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Krugluger W, Brandstaetter A, Kállay E, Schueller J, Krexner E, Kriwanek S, Bonner E, Cross HS Cancer Res. 2007 Aug 15;67(16):7917-22.

Assoc. Prof.in Enikö Kallay, Mag.a, Dr.in

Institut für Pathophysiologie und Allergieforschung, Medizinische Universität Wien

Letzte Aktualisierung: 27.09.2021

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