Expertin
PhD Verena Charwat

Expertise

Biotechnologie: My main research interest is in the interdisciplinary field of biomedical engineering. I use technological approaches to address biological questions and advance biomedical developments. A special focus of my research is the development and application of lab-on-a-chip systems with integrated biosensors for in vitro establishment and non-invasive monitoring of functional tissue mimics. My research is targeted towards creation of physiologically relevant cell culture models including 3D cultivation, co-cultures and dynamic cultivation for basic biological research and biomedical applications.

Schlagworte

  • Zellkultur
  • Mikrofluidik
  • Stammzellen
  • Bioreaktoren
  • Biosensoren

Verfügbar für

    Interviews
    Jury
    Kooperationen
    Mentoring
    Projektleitung
    Projektmitarbeit
    Vortragstätigkeiten

Beruflich

Tätigkeitsbereiche:
  • Wirtschaft / Industrie

Ausbildung

Universität (2014)
Biotechnologie

Weitere Fachrichtungen, weitere Ausbildungen
Medizinische Informatik (BSc) Qualitätsmanagement (DI FH)

Sprachen

  • Deutsch
  • Französisch
  • Englisch
  • Spanisch
Mehr Details
  • Deutsch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Französisch

    Schriftlich: Grundkenntnisse
    Konversation: Grundkenntnisse

  • Englisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Spanisch

    Schriftlich: Grundkenntnisse
    Konversation: Grundkenntnisse

Referenzen

Publikationen

Powell-Palm M. J.*, Charwat V.*, Charrez B*, Siemons B., Healy K. E., and Rubinsky B: “Isochoric supercooled preservation and revival of human cardiac microtissues” Communications biology, 4(1), 1-7 (2021)
Charrez B.*, Charwat V.*, Siemons B.A., Goswami I., Sakolish C., Luo, Y.S., Edwards A.G., Miller E., Rusyn I. and Healy K.E.; „Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID19 Therapeutics“ Frontiers in Pharmacology, 12, p 1831, (2021)
Lee-Montiel F.T.*, Laemmle A.*, Dumont L., Lee C.S., Huebsch N., Charwat V., Okochi H., Hancock M.J., Siemons B., Boggess S.C., Goswami I., Miller E.W., Willenbring H. and Healy K.E.; „Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction“ Frontiers in Pharmacology, 12, p 977 (2021)
Charrez B.*, Charwat V.*, Siemons B., Goswami I., Finsberg H., Miller E., Edwards A.G., Healy K.E.; „In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy“ Clinical and Translational Science (2021)
Jæger K. H., Charwat V., Wall S., Healy K.E. and Tveito A.; „Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems“ Frontiers in Pharmacology, section Cardiovascular and Smooth Muscle Pharmacology, 11, (2020)
Jæger K. H., Charwat V., Charrez B., Finsberg H., Maleckar M.M.C., Wall S., Kevin E. Healy K.E. and Tveito A.; „Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems“ Frontiers in Pharmacology, section Cardiovascular and Smooth Muscle Pharmacology, 10, p 1648, (2020).
Gal N., Charwat V., Kasper C., Städler B., Reimhult E.; „Poly(ethylene glycol) Grafting of Nanoparticles Prevents Uptake by Cells and Transport Through Cell Barrier Layers Regardless of Shear Flow and Particle Size“ ACS Biomater. Sci. Eng., 5, 9, pp 4355-4365 (2019)
Egger D., Oliveira A. C., Mallinger B., Hemeda H., Charwat V., Kasper C.; "From 3D to 3D: isolation of mesenchymal stem/stromal cells into a three-dimensional human platelet lysate matrix“. Stem Cell Research & Therapy, 10, 248 (2019).
Matsumura Y.*, Zhu Y.*, Hongbin Jiang H., D’Amore A., Luketich S.K., Charwat V., Yoshizumi T., Sato H., Yang B., Uchibori T, Healy K.E., Wagner W.R.; „Intramyocardial injection of a fully synthetic hydrogel attenuates left ventricular remodeling post myocardial infarction”, Biomaterials, p 119289 (2019)
Rothbauer, M.*, Charwat, V.*, Bachmann, B.*, Sticker, D.*, Novak, R., Wanzenböck, H., Mathies, R.A. and Ertl, P.; “Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system” Lab on a Chip, 19, pp 1916-1921 (2019)
Burk, J., Holland, H., Lauermann, A.F., May, T., Siedlaczek, P., Charwat, V., Kasper, C.; “Generation and characterization of a functional human adipose‐derived multipotent mesenchymal stromal cell line” Biotechnology and bioengineering, 1–10 (2019)
Charwat V.*; Olmos Calvo I.*; Rothbauer M.; Kratz S.; Jungreuthmayer C.; Zanghellini J.; Grillari J.; Ertl P.; “A Combinatorial in vitro & in silico Approach to Describe Shear-force Dependent Uptake of Nanoparticles in Microfluidic Vascular Models”, Analytical Chemistry 90 (6), pp 3651–3655 (2018)
Mühleder S.; Pill K.; Schaupper M.; Labuda K.; Priglinger E.; Hofbauer P.; Charwat V.; Marx U.; Redl H.; Holnthoner, W.; “The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells.”, Stem cell research & therapy, 9(1), 35. (2018)
Böhm S.; Strauß C.; Stoiber S.; Kasper C.; Charwat V.; “Impact of source and manufacturing of collagen matrices on fibroblast cell growth and platelet aggregation.” Materials, 10(9), 1086. (2017)

15.  Ortmayr K.; Charwat V.; Kasper C.; Hann S.; Koellensperger G.; “Uncertainty budgeting in fold change determination and implications for non-targeted metabolomics studies in model systems”, Analyst 142, pp80-90 (2017)

16.  Gal N.; Lassenberger A.; Herrero-Nogareda L.; Scheberl, A.; Charwat V.; Kasper C.; Reimhult E.; „Interaction of size-tailored PEGylated iron oxide nanoparticles with lipid membranes and cells”, ACS Biomaterials Science & Engineering, 3 (3), pp 249–259 (2017)