Expertin
Dr. DI Hanna Harant

Expertise

Biotechnologie: Biotechnologie, Molekularbiologie, Biochemie, Virologie, Drug Development

Verfügbar für

    Jury
    Kooperationen
    Mentoring
    Projektleitung
    Projektmitarbeit

Beruflich

Oberes Management

Tätigkeitsbereiche:
  • Wirtschaft / Industrie
  • Freiberuflich

Ausbildung

Universität (1995)
Biotechnologie

Sprachen

  • Deutsch
  • Englisch
Mehr Details
  • Deutsch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Englisch

    Schriftlich: Verhandlungssicher / Fließend
    Konversation: Verhandlungssicher / Fließend

Referenzen

Publikationen

1.                    Harant, H. (2022) Selective Inhibition of Murine Cytomegalovirus Viral Gene Expression by the Antiviral Peptide TAT-I24. Int. J. Mol. Sci., 23, 7246.

2.                    Harant, H., Höfinger, S., Kricek, F., Ruf, C., Ruzsics, Z., Hengel, H., Lindley, I.J.D. (2021) The Peptide TAT-I24 with Antiviral Activity against DNA Viruses Binds Double-Stranded DNA with High Affinity. Biologics 2021, 1, 41-60

3.                    Ruzsics, Z., Hoffmann, K., Riedl, A., Krawczyk, A., Widera, M., Sertznig, H., Schipper, L., Kapper-Falcone, V., Debreczeny, M., Ernst, W., Grabherr, R., Hengel, H., Harant, H. (2020). A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication. Frontiers in Microbiology 11, 2934            

4.                    Stadlmann, V., Harant, H., Korschineck, I., Hermann, M., Forster, F., and Missbichler A. (2015). Novel avian single-chain fragment variable (scFv) targets dietary gluten and related natural grain prolamins, toxic entities of celiac disease. BMC Biotechnol. 15:109

5.                    McKibbin, C., Mares, A, Piacenti M., Williams, H., Roboti, P., Puumalainen, M., Callan, A.C., Lesiak-Mieczkowska, K., Linder, S., Harant, H., High, S., Flitsch, S., Whitehead, R.C., and Swanton, E. (2012). Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response. Biochem J. 442, 639-648

6.                    Ballaun, C., Karner, S., Mrass, P., Mildner, M., Buchberger, M., Bach, J., Ban, J., Harant, H., Tschachler, E. and Eckhart, L (2008). Human caspase-14 expression is transcriptionally regulated by AP-1 and NFkB. Biochem. Biophys. Res. Comm 371, 261-266

7.                    Harant, H. TLR7 and TLR8 agonists (2010). in: Progress in Respiratory Research; New Drugs and Targets for Asthma and COPD. Trevor T. Hansel and Peter J Barnes, eds.; Karger AG, Basel.

8.                    Harant, H., Wolff, B., Schreiner, E.P., Oberhauser, B., Hofer, L., Lettner, N., Maier, S., de Vries J.E., Lindley, I.J.D. (2007) Inhibition of vascular endothelial growth factor cotranslational translocation by the cyclopeptolide CAM741. Mol. Pharmacol. 71, 1657-1665

9.                    Oyadomari, S., Yun, C., Fisher, E.A., Kreglinger, N., Kreibich, G., Oyadomari, M., Harding, H.P., Goodman, A.G., Harant, H., Garrison, J.L., Taunton, J., Katze, M.G., Ron D. (2006) Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 126, 727-739

10.                 Harant, H., Lettner, N., Hofer, L., Oberhauser, B., de Vries, J.E., Lindley. I.J.D. (2006) The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. J. Biol. Chem. 281, 30492-30502

11.                 Besemer, J.*, Harant, H.*, Wang, S., Oberhauser, B., Marquardt, K., Foster, C.A., Schreiner, E.P., de Vries, J.E., Dascher-Nadel, C., Lindley, I.J.D. (2005) Selective inhibition of cotranslational translocation of vascular cell adhesion molecule1. Nature 436, 290-293 (*equal contribution)

12.                 Harant, H., Lindley, I.J.D. (2004) Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 32, 5280-5290

13.                 Gruber, F., Hufnagl, P., Hofer-Warbinek, R., Schmid, J.A., Breuss, J.M., Huber-Beckmann, R., Lucerna, M., Papac, N., Harant, H., Lindley, I., de Martin, R., Binder, B.R. (2003) Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF-a-induced PAI-1 expression. Blood 101, 3042-3048

14.                 Harant, H., Eldershaw, S.A., Lindley, I.J.D. (2001) Human macrophage inflammatory protein-3a/CCL20/LARC/Exodus/SCYA20 is transcriptionally upregulated by tumor necrosis factor-a via a non-standard NF-kB site. FEBS Lett. 509, 439-445

15.                 Harant, H., Spinner, D., Lindley, I.J.D. (2000) Natural metabolites of 1a,25-dihydroxyvitamin D3 retain biological activity mediated through the vitamin D receptor. J. Cell. Biochem. 78, 112-120

16.                 Andrew, P.J., Harant, H., Lindley I.J.D. (1999) Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocyte by nitric oxide. Biochem Pharmacol. 57, 1423-1429

17.                 Harant, H. and Lindley, I.J.D. (1998) Interleukin-3. in: Cytokines (Mire-Sluis, A. & Thorpe, R. (eds.)) Academic Press, pp 35-52

18.                 Harant, H., Wolff, B., Lindley, I.J.D. (1998) 1a,25-dihydroxyvitamin-D3 decreases DNA binding of nuclear factor-kB in human fibroblasts. FEBS Lett. 436, 329-334

19.                 Harant, H., Andrew, P.J., Reddy, G.S., Foglar, E., Lindley, I.J.D. (1997) 1a,25-Dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kB-mediated interleukin-8 gene expression. Eur. J. Biochem. 250, 63-71

20.                 Harant, H., de Martin, R., Andrew, P.J., Foglar, E., Dittrich, C., Lindley, I.J.D. (1996) Synergistic activation of interleukin-8 by all-trans retinoic acid and tumor necrosis factor-a involves the transcription factor NF-kB. J. Biol. Chem. 271, 26954-26961

21.                 Krupitza, G., Grill, S., Harant, H., Hulla, W., Szekeres, T., Huber, H., Dittrich, C. (1996) Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells. Br. J. Cancer. 73, 433-438

22.                 Andrew, P.J., Harant, H., Lindley, I.J.D. (1995) Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. Biochem. Biophys. Res. Comm. 214, 949-56

23.                 Harant, H., Lindley, I., Uthman, A., Ballaun, C., Krupitza, G., Grunt, T., Huber, H., Dittrich, C. (1995)  Regulation of interleukin-8 gene expression by all-trans retinoic acid. Biochem. Biophys. Res. Comm. 210, 898-906

24.                 Grunt, T. W., Saceda, M., Martin, M. B., Lupu, R., Dittrich, E., Krupitza, G., Harant, H., Huber, H., Dittrich, C. (1995) Bidirectional interactions between the estrogen receptor and the cerbB-2 signaling pathways: heregulin inhibits estrogenic effects in breast cancer cells. Int. J. Cancer, 63, 560-567

25.                 Krupitza, G., Fritsche, R., Dittrich, E., Harant, H., Huber, H., Dittrich, C. (1995) Macrophage colony-stimulating factor is expressed by an ovarian carcinoma subline and stimulates the c-myc proto-oncogene. Br. J. Cancer 72, 35-40

26.                 Krupitza, G., Hulla, W., Harant, H., Dittrich, E., Kallay, E., Huber, H., Dittrich, C. (1995) Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation. Int. J. Cancer 61, 649-657

27.                 Krupitza, G., Harant, H., Dittrich, E., Szekeres, T., Huber, H., Dittrich, C. (1995) Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells. Carcinogenesis 16 (5), 1199-1205

28.                 Wimmer, K., Harant, H., Reiter, M., Blüml, G., Gaida, Th., Katinger, H. (1994) Two-dimensional gel electrophoresis for controlling and comparing culture supernatants of mammalian cell culture production systems. Cytotechnology 16, 137-146

29.                 Harant, H., Korschineck, I., Krupitza, G., Fazeny, B., Dittrich, C. and Grunt, T.W. (1993) Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription. Br. J. Cancer 68, 530-536

30.                 Plas, C., Wimmer, K., Holubar, P., Mattanovich, D., Danner, H., Jelinek, E., Harant, H. and Braun, R. (1993) Degradation of carbondisulfide by a Thiobacillus isolate. Appl. Microbiol. Biotechnol. 38, 820-823

31.                 Reiter, M., Borth, N., Blüml, G., Wimmer, K., Harant, H., Zach, N., Gaida, Th., Schmatz, C., Katinger, H. (1992) Flow cytometry and two-dimensional electrophoresis (2-DE) for system evaluation of long term continuous perfused animal cell cultures in macroporous beads Cytotechnology 9, 247-253

32.                 Harant, H., Wimmer, K., Wenisch, E., Strutzenberger, K., Reiter, M., Blüml, G., Gaida, Th., Schmatz, C., Katinger, H. (1992) Two-dimensional electrophoresis as a tool for control of quality and consistency in production systems using animal cells Cytotechnology 8, 119-127

33.                 Plas, C., Harant, H., Danner, H., Jelinek, E., Wimmer, K., Holubar, P., Braun, R. (1992) Ratio of biological and chemical oxidation during the aerobic elimination of sulphide by colourless sulphur bacteria Appl. Microbiol. Biotechnol. 36, 817-822

34.                 Plas, C., Wimmer, K., Danner, H., Harant, H., Holubar, P., Braun, R. (1991) Biologische Oxidation von Schwefelkohlenstoff durch ein Thiobacillus-Isolat gwf Wasser-Abwasser 132, 419-421

Hanna Harant
Dr. DI Hanna Harant

Pivaris BioScience GmbH

Letzte Aktualisierung: 30.09.2023