Expertin

Dr. Jutta Horejs-Hoeck

2015                                     AAI Careers in Immunology Fellowship Award

2008                                     Marie Andeßner Mobilitätsförderpreis

2005                                      Research Fellowship,TIGT, Milano, Italy

2004                                     Salzburg Land Research Fellowship

2002                                     Theodor-Körner-Förderungspreis

1. Michelini, S.; Barbero, F.; Prinelli, A.; Steiner, Ph.; Weiss, R.; Verwanger, T.; Andosh, A.; Lütz-Meindl, U.; Puntes, V.F.; Drobne, D.; Duschl, A.; Horejs-Hoeck, J. Gold Nanoparticles (AuNPs) Impair LPS-driven Immune Responses by Promoting a Tolerogenic-like Dendritic Cell Phenotype with Altered Endosomal Structures, Nanoscale, 2021, doi:NR d0nr09153g
2. Urwanisch, L.; Luciano, M.; Horejs-Hoeck, J. The NLRP3 Inflammasome and Its Role in the Pathogenicity of Leukemia. Int. J. Mol. Sci. 2021, doi.org/10.3390/ijms22031271
3. Sarajlic M, Neuper T, Vetter J, Schaller S, Klicznik M, Gratz I, Wessler S, Posselt G, Horejs-Hoeck J. H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression. Cell Commun Signal, 2020, doi: 10.1186/s12964-020-00655-1.
4. Pinsino, A.;   Bastús, N.G.; Busquets-Fité, M.; Canesi, L.; Cesaroni, P.; Drobne,D.; Duschl, A.;   Ewart, M.; Gispert, I.; Horejs-Hoeck, J.; Italiani,P.;  Kemmerling, B.; Kille, P.; Procházková, P.;  Puntes, V.F.; Spurgeon, D.J.; Svendsen, C.; Wilde, C.J.; Boraschi, D.; Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA. Environ. Sci.: Nano, 2020, 7, 3216-3232, doi.org/10.1039/D0EN00732C
5. Chichirau BE, Scheidt T, Diechler S, Neuper T, Huber C, Horejs-Hoeck J, Posselt G, Wessler S. Dissecting the Helicobacter pylori-regulated transcriptome of B cells. Pathog Dis, 2020, Aug 31:ftaa049. doi: 10.1093/femspd/ftaa049.
6. Winter, P.; Stubenvoll, S.; Scheiblhofer, S.; Joubert, I.A.; Strasser, L.; Briganser, C.; Soh, W.T.; Hofer, F.; Kamenik, A.S.; Dietrich, V.; Michelini, S.;  Laimer, J.; Lackner, P.; Horejs-Hoeck, J.; Tollinger, M.; Liedl,K.R.;  Brandstetter, J.; Huber, C.G.; Weiss, R. "In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization", Frontiers in Immunology, 2020, doi: 10.3389/fimmu.2020.01824.
7. Neuper, T., Neureiter. D., Schwarz, H., Sarajlic, M., Bauer, R., Strandt, H., Suchanek, P., Dillon, S.R., Stoecklinger, A., Hammerl, P., Weiss, R., and Horejs-Hoeck, J. Reduced allergen-induced lung inflammation in IL-31 transgenic mice, European Journal of Immunology, 2020, doi.org/10.1002/eji.202048547.
8. Korotchenko, E.; Schießl, V.;  Scheiblhofer, S.; Joubert, I.A.; Strandt, H.; Neuper, T.; Sarajlic,M.;  Bauer, R.; Geppert, M.; Joedicke, D.; SWildner, S.; Schaller, S.; Winkler, S.; Gadermaier, G.; Horejs-Hoeck, J.; Weiss R.; Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma, Allergy, 2020, doi: 10.1111/all.14481
9. Klicznik Maria M., Ariane Benedetti, Laura M. Gail, Suraj R. Varkhande, Raimund Holly, Martin Laimer, Angelika Stoecklinger, Andreas Sir, Roland Reitsamer, Theresa Neuper, Jutta Horejs-Hoeck, Michael D. Rosenblum, Daniel J. Campbell, Eva M. Murauer, Iris K. Gratz A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin.  Scientific Reports, 2020, doi: 10.1038/s41598-020-67430-7
10. Neuper, T.; Frauenlob, T.; Sarajlic, M.; Posselt, G.; Wessler, S.; Horejs-Hoeck, J.; TLR2, TLR4 and TLR10 shape the cytokine and chemokine release of H. pylori-infected human DCs.  Int J Mol Sci, 2020 May 29;21(11):E3897. doi: 10.3390/ijms21113897
11. Joubert, I.A.; Geppert, M.; Johnson, L.; Mills-Goodlet, T.; Michelini, S.; Korotchenko, E.; Duschl, A.; Weiss, R.; Horejs-Höck, J.; Himly, M.; Mechanisms of particles in sensitization, effector function and therapy of allergic disease, Frontiers in Immunology, 2020, Jun 30;11:1334. doi: 10.3389/fimmu.2020.01334
12. Korotchenko, E.; Moya, R.; Scheiblhofer, S.; Joubert, I.A.; Horejs-Hoeck, J., Hauser, M.; Calzada, D.; Iraola,  V.; Carnés, J.; Weiss, R.; Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation. Allergy, 2020 May;75(5):1217-1228. doi: 10.1111/all.14164. Epub 2020 Jan 29. PMID: 31880319
13. Boraschi, D.; Alijagic, A.; Auguste. M.; Barbero, F.; Ferrari, E.; Hernadi, S.; Mayall, C.; Michelini, S.; Navarro Pacheco, N.I., Prinelli, A.; Swart, E.; Swartzwelter, B.J.;  Bastús, N.G.; Canesi, L.; Drobne, D.; Duschl, A.; Ewart, M.; Horejs-Hoeck, J.; Italiani, P.; Kemmerling, B.; Kille, P.; Prochazkova, Puntes, V.F.; Spurgeon, D.V.; Svendsen, C.; Wilde, C.J.; Pinsino, A.;  Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. Small. 2020 May 4:e2000598. doi: 10.1002/smll.202000598.
14. Himly, M.; Geppert, M.; Hofer, S.; Hofstätter, N.; Horejs-Höck, J.; Duschl, A.; When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety. Small 2020. DOI smll.201907483
15. Sarajlic, M.; Neuper, T.; Fohrenbach Quiroz, K. T.; Michelini, S.; Vetter, J.; Schaller, S.; Horejs-Hoeck, J.,  IL-1β Induces SOCS2 Expression in Human Dendritic Cells. Int J Mol Sci 2019, 20 (23). DOI 10.3390/ijms20235931.
16. Samadi N, Klems M, Heiden D, Bauer R, Kitzmüller C, Weidmann E, Ret D, Ondracek AS, Duschl A, Horejs-Hoeck J, Untersmayr E. Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model, Allergy, 2019, Aug 24. doi: 10.1111/all.14030.
17. Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang HH, Briza P, Bohle B, Horejs-Hoeck J, Traidl-Hoffmann C, Ferreira F. Context matters: Th2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity. J Allergy Clin Immunol, 2018, 18: 30711-30715. doi: 10.1016/j.jaci.2018.05.004.
18. Michelini S, Sarajlic M, Duschl A, Horejs-Hoeck J. Dendritic cell activation and feedback inhibition in sterile and non-sterile inflammation. Hum Immunol, 2018, 79:610-615. doi: 10.1016/j.humimm.2018.06.002
19. Binder S, Luciano M, Horejs-Hoeck, J. The Cytokine Network in Acute Myeloid Leukemia (AML): A Focus on Pro- and Anti-Inflammatory Mediators, Cytokine and Growth Factor reviews, 2018, Oct;43:8-15. doi: 10.1016/j.cytogfr.2018.08.004.
20. Strasser L, Schwarz H, Dang HH, Asam C, Ferreira F, Horejs-Hoeck J, Huber CG. Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells. Sci Rep, 2017, 7:16638. doi: 10.1038/s41598-017-16726-2
21. Li  Y, Zhenzhen S, Radauer-Preiml  I,  Ancuela A, Casals  E, Luetz-Meindl U, Cobal M, Zhoumeng  L,  Jaberi-Douraki M, Italiani P,  Horejs-Hoeck  J,  Himly M,  Monteiro-Riviere NA, Duschl A, Puntes V,  Boraschi D. Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation. Nanotoxicology, 2017, 11:1157-1175. doi: 10.1080/17435390
22. Neuper T, Ellwanger K, Schwarz H, Kufer TA, Duschl A, Horejs-Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep, 2017, 7:1005. doi: 10.1038/s41598-017-00691-x.
23. Schwarz H, Gornicec J, Neuper T, Parigiani MA, Wallner M, Duschl A, Reich J, Horejs-Hoeck J. Biological Activity of Masked Endotoxin. Sci Rep, 2017, 7: 44750. doi: 10.1038/srep44750
24. Radauer-Preiml I, Andosch A, Hawranek T, Luetz-Meindl U, Huber C, Wiederstein M, Horejs-Hoeck J, Himly M, Boyles MSP, Duschl A. Human allergic response modulated by interactions of allergens with gold nanoparticles – protein corona characterization and basophil response, Part Fibre Toxicol, 2016, 3: 3. doi: 10.1186/s12989-016-0113-0
25. Steiner M, Hawranek T, Schneider M, Harrer A, Horejs-Hoeck J, Ferreira F, Himly M. Elevated Toll-like receptor-induced CXCL8 secretion in human blood basophils from allergic donors is independent of Toll-like receptor expression levels. PlosOne, 2016 11: e0149275. doi: 10.1371/journal.pone.0149275
26. Maier E, Mittermaier M, Ess S, Neuper T, Schmiedlechner A, Duschl A, Horejs-Hoeck J. Prerequisites for functional Interleukin 31 Signaling and Feedback Regulation by Suppressors of Cytokine Signaling (SOCS). J Biol Chem, 2015, 290: 24747-24759. doi: 10.1074/jbc.M115.661306
27. Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs J, Wallnöfer H, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. Fold-stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. J Allergy Clin Immunol, 2015, 7: 1525-1534. doi:10.1016/j.jaci.2015.09.026