Expertin
Ass.-Prof. Priv.-Doz. Dr.rer.nat. Mélanie Hall

Expertise

Chemie

Schlagworte

  • Biokatalyse
  • Organische Chemie
  • Biotechnologie
  • Enzyme
  • Nachhaltigkeit

Verfügbar für

    Jury
    Kooperationen
    Mentoring
    Projektleitung
    Vortragstätigkeiten

Beruflich

Mittleres Management

Tätigkeitsbereiche:
  • Universität

Ausbildung

Universität (2007)
Chemie

Sprachen

  • Englisch
  • Deutsch
  • Französisch
Mehr Details
  • Englisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Deutsch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Französisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

Referenzen

Auszeichnungen / Preise

National Habilitation Award 2016 of the Austrian Chemical Society (GÖCH) 

Anton-Paar Award of Science 2013 of the Austrian Chemical Society (GÖCH) 

Publikationen

43)    R. C. Cioc, V. Estévez, D. J. van der Niet, C. M. L. Vande Velde, N. G. Turrini, M. Hall, K. Faber, E. Ruijter, R. V. A. Orru, Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids, Eur. J. Org. Chem., 2017, 1262-1271.

42)    N. G Turrini, R. C. Cioc, D. J. van der Niet, E. Ruijter, R. V. A. Orru, M. Hall, K. Faber, Biocatalytic Access to Nonracemic g-Oxo Esters via Stereoselective Reduction Using Ene-Reductases, Green Chem., 2017, 19, 511-518.

41)    N. G. Turrini, E. Eger, T. C. Reiter, K. Faber, M. Hall, Sequential Enzymatic Conversion of a-Angelica Lactone to g-Valerolactone via Hydride-Independent C=C Bond Isomerization, ChemSusChem, 2016, 9, 3393-3396.

40)    M. Fink, S. Trunk, M. Hall, H. Schwab, K. Steiner, Engineering of TM1459 from Thermotoga maritima for increased oxidative alkene cleavage activity, Front. Microbiol., 2016, 7, 1511.

39)    Z. Assaf, K. Faber, M. Hall, Scope, Limitations and Classification of Lactamases, J. Biotechnol., 2016, 235, 11-23.

38)    J. Gross, Z. Prokop, D. Janssen, K. Faber, M. Hall, Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB, ChemBioChem., 2016, 17, 1437-1441.

37)    G. Tasnádi, M. Hall, K. Baldenius, K. Ditrich, K. Faber, Biocatalytic Functionalization of Hydroxyalkyl Acrylates and Phenoxyethanol via Phosphorylation, J. Biotechnol., 2016, 233, 219-227.

36)    A. Dennig, S. Kurakin, M. Kuhn, A. Dordic, M. Hall, Kurt Faber, Enzymatic Oxidative Tandem Decarboxylation of α,ω-Dioic Acids to α,ω-Dienes, Eur. J. Org. Chem., 2016, 21, 3473-3477.

35)    F. Fiorentini, M. Geier, C. Binda, M. Winkler, K. Faber, M. Hall*, A. Mattevi*, Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans, ACS Chem. Biol., 2016, 11, 1039-1048.

34)    G. Tasnádi, M. Lukesch, M. Zechner, W. Jud, M. Hall, K. Ditrich, K. Baldenius, A. F. Hartog, R. Wever, K. Faber, Exploiting Acid Phosphatases in the Synthesis of Phosphorylated Monoalcohols and Diols, Eur. J. Org. Chem., 2016, 45-50.

33)    M. Geier, C. Brandner, G. A. Strohmeier, M. Hall, F. S. Hartner, A. Glieder, Engineering Pichia pastoris for Improved NADH Regeneration: A Novel Chassis Strain for Whole-Cell Catalysis, Beilstein J. Org. Chem., 2015, 11, 1741-1748.

32)    I. Hajnal, K. Faber, H. Schwab, M. Hall*, K. Steiner*, Oxidative Alkene Cleavage Catalysed by Manganese-dependent Cupin TM1459 from Thermotoga maritima, Adv. Synth. Catal., 2015, 357, 3309-3316.

Highlighted in Nat. Prod. Rep., 2016, 33, 122.

31)    A. Dennig, M. Kuhn, S. Tassoti, A. Thiessenhusen, S. Gilch, T. Bülter, T. Haas, M. Hall, K. Faber, Oxidative Decarboxylation of Short-Chain Fatty Acids to 1-Alkenes, Angew. Chem. Int. Ed., 2015, 54, 8819-8822.

Selected as VIP Paper | Highlighted in Synfacts, 2015, 11, 0993 and Nat. Prod. Rep., 2015, 32, 1364.

30)    N. G. Turrini, M. Hall, K. Faber, Enzymatic Synthesis of Optically Active Lactones via Asymmetric Bioreduction Using Ene-Reductases from the Old Yellow Enzyme Family, Adv. Synth. Catal., 2015, 357, 1861-1871.

Selected as VIP Paper | Highlighted in Nat. Prod. Rep., 2015, 32, 1364.

29)    Z. Assaf, E. Eger, Z. Vitnik, W. M. Fabian, D. Ribitsch, G. M. Guebitz, K. Faber, M. Hall, Identification and Application of Enantiocomplementary Lactamases for Vince Lactam Derivatives, ChemCatChem, 2014, 6, 2517-2521.

28)    K. Durchschein, M. Hall, K. Faber, Unusual reactions mediated by FMN-dependent ene- and nitro-reductases, Green Chem., 2013, 15, 1764-1772.

27)    C. Wuensch§, H. Lechner§, S. M. Glueck, K. Zangger, M. Hall*, K. Faber*, Asymmetric Biocatalytic Cannizzaro-Type reaction, ChemCatChem, 2013, 5, 1744-1748.

26)    G. Oberdorfer, A. Binter, S. Wallner, K. Durchschein, M. Hall, K. Faber, P. Macheroux, K. Gruber, The structure of glycerol trinitrate reductase NerA from Agrobacterium radiobacter reveals the molecular reason for nitro- and ene-reductase activity in OYE homologues, ChemBioChem, 2013, 14, 836-845.

25)    C. K. Winkler, G. Tasnádi, D. Clay, M. Hall, K. Faber, Asymmetric Bioreduction of Activated Alkenes to Industrially Relevant Optically Active Compounds, J. Biotechnol., 2012, 162, 381-389.

24)    G. Oberdorfer, K. Gruber, K. Faber*, M. Hall*, Stereocontrol Strategies in the Asymmetric Bioreduction of Alkenes, Synlett, 2012, 23, 1857-1864.

23)    G. Tasnádi, C. K. Winkler, D. Clay, N. Sultana, W. M. F. Fabian, M. Hall, K. Ditrich, K. Faber, A Substrate-Driven Approach to Determine Reactivities of a,b-Unsaturated Carboxylic Esters Towards Asymmetric Bioreduction, Chem. Eur. J., 2012, 18, 10362-10367.

22)    G. Tasnádi, C. K. Winkler, D. Clay, M. Hall, K. Faber, Reductive Dehalogenation of b-Haloacrylic Ester Derivatives Mediated by Ene-Reductases#, Catal. Sci. Technol., 2012, 2, 1548-1552.

Selected as a Catalysis Science & Technology Hot Article.

21)    B. T. Uebarbacher, M. Hall*, K. Faber*, Electrophilic and Nucleophilic Enzymatic Cascade Reactions in Biosynthesis#, Nat. Prod. Rep., 2012, 29, 337-350.

Among the top 10 accessed articles from the journal online version February 2012.

20)    P. Bansal, B. J. Vowell, M. Hall, M. J. Realff, J. H. Lee, A. S. Bommarius, Elucidation of Cellulose Accessibility, Hydrolysability and Reactivity as the Major Limitations in the Enzymatic Hydrolysis of Cellulose, Bioresour. Technol., 2012, 107, 243–250.

19)    M. Hall§, J. Rubin§, S. Behrens, A. S. Bommarius, The cellulose-binding domain of cellobiohydrolase Cel7A from Trichoderma reesei is also a thermostabilizing domain, J. Biotechnol., 2011, 155, 370-376.

18)    M. Hall§ and A. S. Bommarius§, Enantioenriched compounds via enzyme-catalyzed redox reactions#, Chem. Rev., 2011, 111, 4088-4110.

17)    C. Stueckler, C. K. Winkler, M. Hall, B. Hauer, M. Bonnekessel, K. Zangger, K. Faber, Stereo-Controlled Asymmetric Bioreduction of a,b-Dehydroamino Acid Derivatives, Adv. Synth. Catal., 2011, 353, 1169-1173.

16)    Y. Yanto, C. K. Winkler, S. Lohr, M. Hall, K. Faber, A. S.  Bommarius, Asymmetric Bioreduction of Alkenes Using Ene-Reductases YersER and KYE1, and Effects of Organic Solvents, Org. Lett., 2011, 13, 2540-2543.

15)    K. Tauber, M. Hall, W. Kroutil, W. M. F. Fabian, K. Faber, S. Glueck, A Highly Efficient ADH-Coupled NADH-Recycling System for the Asymmetric Bioreduction of C=C Double Bonds using Enoate Reductases, Biotechnol. Bioeng., 2011, 108, 1462-1467.

14)    M. Hall, P. Bansal, J. H. Lee, M. J. Realff, A. S. Bommarius, Biological pretreatment of cellulose: Enhancing enzymatic hydrolysis rate using cellulose-binding domains from cellulases, Bioresour. Technol., 2011, 102, 2910-2915.

13)    Y. Yanto, H.-H. Yu, M. Hall, A. S. Bommarius, Characterization of Xenobiotic Reductase A (XenA): Study of Active Site Residues, Substrate Spectrum and Stability, Chem. Commun., 2010, 46, 8809-8811.

12)    Y. Yanto, M. Hall, A. S. Bommarius, Nitroreductase from Salmonella typhimurium: characterization and catalytic activity, Org. Biomol. Chem., 2010, 8, 1826-1832.

11)    M. Hall, P. Bansal, J. H. Lee, M. J. Realff, A. S. Bommarius, Cellulose Crystallinity: A Key Predictor of Enzymatic Hydrolysis Rate, FEBS J., 2010, 277, 1571-1582.

FEBS Journal Top-Cited Paper Award (as one of the top 10 most-cited FEBS Journal papers two years from publication).

10)    P. Bansal, M. Hall, M. J. Realff, J. H. Lee, A. S. Bommarius, Multivariate statistical analysis of X-ray data from cellulose: A new method to determine degree of crystallinity and predict hydrolysis rates, Bioresour. Technol., 2010, 101, 4461-4471.

9)      P. Bansal, M. Hall, M. J. Realff, J. H. Lee, A. S. Bommarius, Modeling Cellulase Kinetics On Lignocellulosic Substrates, Biotechnol. Adv., 2009, 27, 833-848.

8)      N. J. Mueller, C. Stueckler, M. Hall, P. Macheroux, K. Faber. Epoxidation of conjugated C=C-bonds and sulfur-oxidation of thioethers mediated by NADH:FMN-dependent oxidoreductases, Org. Biomol. Chem., 2009, 7, 1115-1119.

7)      M. Hall, C. Stueckler, B. Hauer, R. Stuermer, T. Friedrich, M. Breuer, W. Kroutil, K. Faber. Asymmetric Bioreduction of Activated C=C-Bonds Using Zymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1-3 from Yeasts#, Eur. J. Org. Chem., 2008, 1511-1516.

6)      M. Hall, C. Stueckler, H. Ehammer, E. Pointner, G. Oberdorfer, K. Gruber, B. Hauer, R. Stuermer, W. Kroutil, P. Macheroux, K. Faber. Asymmetric Bioreduction of C=C Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol, Adv. Synth. Catal., 2008, 350, 411-418.

Featured as one of the journal articles the most frequently cited among those published in 2008 or 2009 that have contributed the most to the journal's impact factor in 2010.

5)      C. Stueckler, M. Hall, H. Ehammer, E. Pointner, W. Kroutil, P. Macheroux, K. Faber. Stereo-Complementary Bioreduction of a,b-Unsaturated Dicarboxylic Acids and Dimethyl Esters using Enoate Reductases: Enzyme- & Substrate-Based Stereocontrol, Org. Lett., 2007, 9, 5409-5411.

4)      M. Hall, C. Stueckler, W. Kroutil, P. Macheroux, K. Faber. Asymmetric Bioreduction of Activated Alkenes Using Cloned 12-Oxophytodienoate Reductase Isoenzymes OPR-1 and OPR-3 from Lycopersicon esculentum (Tomato): A Striking Switch of Stereopreference, Angew. Chem. Int. Ed., 2007, 46, 3934-3937.

Highlighted in Synfacts, 2007, 7, 0757. 

3)      R. Stuermer, B. Hauer, M. Hall, K. Faber. Asymmetric Bioreduction of Activated C=C Bonds Using Enoate Reductases from the Old Yellow Enzyme Family, Curr. Opinion Chem. Biol., 2007, 11, 203-213.

2)      M. Hall, B. Hauer, R. Stuermer, W. Kroutil, K. Faber. Asymmetric Whole-Cell Bioreduction of an a,b-Unsaturated Aldehyde (Citral): Competing prim-Alcohol Dehydrogenase and C-C Lyase Activities, Tetrahedron: Asymmetry, 2006, 17, 3058-3062.

1)      B. M. Nestl, S. M. Glueck, M. Hall, W. Kroutil, R. Stuermer, B. Hauer, K. Faber. Biocatalytic Racemization of (Hetero)Aryl-aliphatic α-Hydroxycarboxylic Acids by Lactobacillus spp. Proceeds via an Oxidation-Reduction Sequence, Eur. J. Org. Chem., 2006, 4573-4577.

Mélanie Hall
Ass.-Prof. Priv.-Doz. Dr.rer.nat. Mélanie Hall

Institut für Chemie

Kontakt

Letzte Aktualisierung: 27.09.2021