Expertin
Assoc. Prof.in Dr.in rer.nat. Nataliya Rohr-Udilova

Expertise

Humanmedizin

Schlagworte

  • Krebsforschung
  • Zellkultur
  • akademische Lehre
  • hepatozelluläres Karzinom
  • Kolonkarzinoma
  • Antioxidantien
  • Selen
  • Tumorbiologie
  • in vitro Toxizitätsbewertung
  • oxidierte Fettsäuren

Verfügbar für

    Gender-Trainings
    Interviews
    Jury
    Kooperationen
    Mentoring
    Projektleitung
    Projektmitarbeit
    Vortragstätigkeiten

Beruflich

Mittleres Management

Tätigkeitsbereiche:
  • Universität

Ausbildung

Universität (1992)
Naturwissenschaften

Zusatzausbildung(en)
Tumor Biologie, postgraduell, akademisch geprüft

Weitere Fachrichtungen, weitere Ausbildungen
Biophysik, angewandte Physik und Mathematik

Sprachen

  • Deutsch
  • Russisch
  • Ukrainisch
  • Englisch
  • Französisch
Mehr Details
  • Deutsch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Russisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Ukrainisch

    Schriftlich: Muttersprache / wie Muttersprache
    Konversation: Muttersprache / wie Muttersprache

  • Englisch

    Schriftlich: Verhandlungssicher / Fließend
    Konversation: Verhandlungssicher / Fließend

  • Französisch

    Schriftlich: Grundkenntnisse
    Konversation: Grundkenntnisse

Referenzen

Publikationen

Udilova N., Popov I.N., Lewin G.I., Vladimirov Yu.A. Antioxidant properties of UV-irradiated blood plasma and its components as determined by method of photochemiluminescence. Biofizika 1997;42 (1); 187-190.               (0.435 IP)
Stolze K., Udilova N., Nohl, H. Spin trapping of lipid radicals with DEPMPO derived spin traps: Detection of superoxide, alkyl and alkoxyl radicals in aqueous and lipid phase.  Free Radic. Biol. Med. (2000) Nov. 15; 29(10):1005-14.                   (5.707 IP)
Stolze, K; Udilova, N; Nohl, H Lipid radicals: Properties and detection by spin trapping Acta Biochim. Pol. (2000) 47 (4): 923-930.                                                  (1.363 IP)
Stolze, K., Udilova, N., Nohl, H. ( 2002): ESR analysis of spin adducts of alkoxyl and lipid-derived radicals with the spin trap Trazon . Biochemical Pharmacology 63, (8), 1465-1470.                                                                                                     (4.889 IP)
Stolze K., Udilova N., Nohl H. Spin adducts of superoxide, alkoxyl and lipid-derived radicals with EMPO and its derivatives. Biol. Chem. May 2002, 383(5):813-20.                                                                                                                        (2.965 IP)
Gille L., Schott-Ohly P., Friesen N., Schulte im Walde S., Udilova N., Nohl H., Gleichmann H. Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro. Pharmacology and Toxicology  (2002), 90(6):317-26.
Udilova, N., Kozlov, A. V., Bieberschulte, W., Frei, K., Ehrenberger, K., Nohl, H. ( 2003): The antioxidant activity of caroverine. Biochemical Pharmacology 65, 59-65.                                                                                                                   (4.889 IP)
Nohl, H., Bieberschulte, W., Dietrich, B., Udilova, N., Kozlov, A. ( 2003): Caroverine a multifunctional drug with antioxidant functions. BioFactors 19, 79-85.       (4.504 IP)
Stolze, K., Udilova, N., Rosenau, T., Hofinger, A., Nohl, H. ( 2003): Spin trapping of superoxide, alkyl- and lipid-derived radicals with derivatives of the spin trap EPPN.
Biochemical Pharmacology 66, 1717-1726.                                                   (4.889 IP)
Stolze, K., Udilova, N., Rosenau, T., Hofinger, A., Nohl, H. ( 2003): Synthesis and characterization of EMPO-derived 5,5-disubstituted 1-pyrroline N-oxides as spin traps forming exceptionally stable superoxide spin adducts. Biological Chemistry 384, (3), 493-500.                                                                                                  (2.965 IP)
Udilova, N., Jurek, D., Marian, B., Gille, L., Schulte-Hermann, R., Nohl, H. ( 2003): Induction of lipid peroxidation in biomembranes by dietary oil components . Food and Chemical Toxicology 41, 1481–1489.                                                          (3.584 IP)
Grzenkowicz-Wydra J., Cisowski J., Nakonieczna J., Zarębski A., Udilova N., Nohl H., Józkowicz A., Podhajska A., Dulak J. (2004) Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor. Molecular and Cellular Biochemistry Sep; 264(1-2):169-81.                                      (1.862 IP)
Jurek D., Udilova N.(contributed equally), Jozkowitz A., Nohl H., Marian B., Schulte-Hermann R (2005) Dietary lipid peroxides induce expression of vascular endothelial growth factor (VEGF) in colorectal tumor cells. FASEB Journal 19(1), 97-99.                                                                                                                          (6.791 IP)
Stolze, K., Udilova, N., Rosenau, T., Hofinger, A., Nohl, H. ( 2004): Spin Adducts of Several EPPyN Derivatives with Superoxide, Alkyl and Lipid-Derived Radicals. Biochemical Pharmacology; 68(1):185-94.                                                    (4.889 IP)
Stolze, K., Udilova, N., Rosenau, T., Hofinger, A., Nohl, H. ( 2005): Spin Adduct Formation from Lipophilic EMPO-Derived Spin Traps with Various Oxygen- and Carbon-centered Radicals. Biochemical Pharmacology, 69(2):297-305.            (4.889 IP)
Stolze, K., Rohr-Udilova, N., Rosenau, T., Hofinger, A., Nohl, H. (2005): Very Stable Superoxide Radical Adducts Formed from 5-Ethoxy-carbonyl-3,5-dimethyl-pyrroline N-Oxide (3,5-EDPO) and its Derivatives. Biochemical Pharmacology,  69(9), 1351-1361.                                                                                                                 (4.889 IP)
Rohr-Udilova, N., Stolze, K., Marian B., Nohl, H. (2006) Cytotoxicity of novel derivatives of the spin trap EMPO. Bioorganic & Medicinal Chemistry Letters Feb;16(3):541-6. Epub 2005 Nov 10.                                                  (2.661 IP)
Nohl H, Rohr-Udilova N, Gille L, Bieberschulte W, Jurek D, Marian B, Schulte-Herman R. Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone. Anticancer Res. 2005 Jul-Aug; 25(4):2793-800.                                                                                               (1.479 IP)
Nohl H, Rohr-Udilova N, Gille L, Bieberschulte W, Jurek D, Marian B, Schulte-Hermann R. Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat. Biofactors. 2005; 25(1-4):87-95.                                   (4.504 IP)
Stolze K., Rohr-Udilova N., Rosenau T., Hofinger A., Kolarich D., Nohl H. ( 2006) Spin Trapping of C- and O-Centered Radicals with Methyl, Ethyl-, Pentyl- and Phenyl-Substituted EMPO Derivatives. Bioorganic & Medicinal Chemistry May 15;14(10):3368-76.                                                                                        (2.978 IP)
Stolze K., Rohr-Udilova N., Rosenau T., Hofinger A., Nohl H. (2007) Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO). Bioorganic and Medicinal Chemistry Apr 15;15(8):2827-36.                                                                                      (2.978 IP)
Rohr-Udilova N, Stolze K, Sagmeister S, Parzefall W, Marian B, Nohl H, Schulte-Hermann R, Grasl-Kraupp B.Cytotoxicity of the novel spin trapping compound 5-ethoxycarbonyl-3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives.Bioorg Med Chem Lett. 2007 Oct 15;17(20):5698                       
Rohr-Udilova NV, Stolze K, Sagmeister S, Nohl H, Schulte-Hermann R, Grasl-Kraupp B. Lipid hydroperoxides from processed dietary oils enhance growth of hepatocarcinoma cells. Mol Nutr Food Res. 2008 Mar;52(3):352-9.              
Kaindl U, Eyberg I, Rohr-Udilova N, Heinzle C, Marian B. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem. Toxicol. 2008 Apr;46(4):1320-6.                                                      
Stolze K, Rohr-Udilova N, Hofinger A, Rosenau T. Spin trapping experiments with different carbamoyl-substituted EMPO derivatives. Bioorg Med Chem. 2008 Sep 1;16(17):8082-9.                                                                                          
Sagmeister S., Drucker C., Losert A., Grusch M., Daryabeigi A.,  Parzefall W., Rohr-Udilova N., Bichler C., Smedsrød B., Kandioler D., Grünberger T., Wrba F., Rolf Schulte-Hermann R., Grasl-Kraupp B. HB-EGF is a paracrine growth stimulator for early tumor-prestages in inflammation-associated hepatocarcinogenesis. J Hepatol. 2008 Dec;49(6):955-64.                                                                            
Stolze K, Rohr-Udilova N, Hofinger A, Rosenau T. Synthesis and characterization of several carbamoyl- and methylcarbamoyl-substituted EMPO derivatives. Bioorg Med Chem. 2009, Nov 1; 17(21):7572-84.                                                                  
Stockhammer S., Stolze K., Rohr-Udilova N., Chizzola R., Zitterl-Eglseer K., Franz C. Antioxidant activity of phytigenous industrial waste and derived extracts fort he production of feed and food additives. Int. J. Food Sci. Techn. 2009, 44: 702-710.
Reiberger T, Angermayr B, Schwabl P, Rohr-Udilova N, Mitterhauser M, Gangl A, Peck-Radosavljevic M. Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats. J Hepatol. 2009, Nov; 51(5):865-73.            (11.336
Stolze K, Rohr-Udilova N, Patel A, Rosenau T. Synthesis and characterization of 5-hydroxymethyl-5-methyl-pyrroline N-oxide and its derivatives. Bioorg Med Chem. 2011 Jan 15;19(2):985-93.                                                                               
Patel A, Rohr-Udilova N, Rosenau T, Stolze K. Synthesis and characterization of 5-alkoxycarbonyl-4-hydroxymethyl-5-alkyl-pyrroline N-oxide derivatives. Bioorg Med Chem. 2011 Dec 15;19(24):7643-52.                                                                  
Rohr-Udilova N, Sieghart W, Eferl R, Stoiber D, Björkhem-Bergman L, C Eriksson L, Stolze K, Hayden H, Keppler B, Sagmeister S, Grasl-Kraupp B, Schulte-Hermann R, Peck-Radosavljevic M. Antagonistic effects of selenium and lipid peroxides on  growth control in early hepatocellular carcinoma. Hepatology. 2012, 55(4):1112-21                                                                                                               
Pinter M, Sieghart W, Reiberger T, Rohr-Udilova N, Ferlitsch A, Peck-Radosavljevic M. The effects of sorafenib on the portal hypertensive syndrome in patients with liver cirrhosis and hepatocellular carcinoma--a pilot study. Aliment Pharmacol Ther. 2012 Jan;35(1):83-91.                                                                                            
Sieghart W, Pinter M, Dauser B, Rohr-Udilova N, Piguet AC, Prager G, Hayden H, Dienes HP, Dufour JF, Peck-Radosavljevic M 1. Erlotinib and sorafenib in an orthotopic rat model of hepatocellular carcinoma. J Hepatol. 2012 Sep;57(3):592-9                                                                                                                           

T. Böhm, H. Berger, M. Nejabat, T. Riegler, F. Kellner, M. Kuttke, S. Sagmeister, M. Bazanella, K. Stolze, A. Daryabeigi, N. Bintner, M. Murkovic, K.-H. Wagner, R. Schulte-Hermann, N. Rohr-Udilova (alternative corresponding author), W. Huber, B. Grasl-Kraupp. Food-derived peroxidized fatty acids may trigger hepatic inflammation: a novel hypothesis to explain steatohepatitis. J Hepatol. 2013 Vol.59, 563-570. 

L. Bamonti, S. Theiner, N. Rohr-Udilova, B. K. Keppler and  G. Koellensperger.   Accurate high throughput quantification of selenium in biological samples – the potential of combining isotope dilution ICP-tandem mass spectrometry with flow injection. J. Anal. At. Spectrom., 2016,31, 2227-2232 
Philipp Schwabl, Eva Hambruch, Berit A. Seeland, Hubert Hayden, Michael Wagner, Lukas Garnys, Bastian Strobel, Tim-Lukas Schubert, Florian Riedl, Dieter Mittereger, Michael Burnet, Patrick Starlinger, Georg Oberhuber, Ulrich Deuschle, Nataliya Rohr-Udilova, Bruno K. Podesser, Markus Peck-Radosavljevic, Thomas Reiberger, Claus Kremoser, Michael Trauner. The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodeling and sinusoidal dysfunction. J Hepatol.  2017 66: 724-733 
Claudia D. Fuchs, Gustav Paumgartner, Annika Wahlström, Philipp Schwabl, Thomas Reiberger, Nadja Leditznig, Tatjana Stojakovic, Nataliya Rohr-Udilova, and others. Metabolic preconditioning protects BSEP/ABCB11−/− mice against cholestatic liver injury. J. Hepatol, 2017, Vol. 66, Issue 1, p95–101 
Sandra Rebouissou, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Anna-Line Calatayud, Nataliya  Rohr-Udilova, Yoann Martin, Gabrielle Couchy, Paulette Bioulac-Sage, B. Grasl-Kraupp, Leanne de Koning, Nathalie Ganne-Carrie, Jean-Charles Nault, Marianne Ziol, and Jessica Zucman-Rossi. Proliferation markers are associated with MET expression in hepatocellular carcinoma and predict tivantinib sensitivity in vitro. Clin Cancer Res. 2017 Aug 1;23(15):4364-4375 
Rohr-Udilova N, Klinglmuller F, Seif M, Hayden H, Bilban M, Pinter M, Stolze K, Sieghart W, Peck-Radosavljevic M, Trauner M (2017) Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib. Oncotarget. 2017 Jul 6;8(34):57109-57120. 
Guo H, Eleftheriadis N, Rohr-Udilova N, Dömling A, Dekker FJ (2017) 2-aminopyrroles as photoactivatable inhibitors of human 15-lipoxygenase-1.  Eur J Med Chem. 2017 Oct 20;139:633-643. 
N. Rohr-Udilova, E. Bauer, G. Timelthaler, R. Eferl, K. Stolze, M. Pinter, M. Seif, H. Hayden, T. Reiberger,  R. Schulte-Hermann, M. Peck-Radosavljevic, D. Stoiber, M. Trauner. Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma. Oncotarget. 2018 Jan 22;9(11):10054-10068 
N. Rohr-Udilova, F. Klinglmüller, R. Schulte-Hermann, M. Pinter, T. Reiberger, R.  Eferl,  M. Trauner. Deviations of the immune cell landscape between healthy liver and hepatocellular carcinoma. Scientific Reports  2018 Apr 18;8(1):6220 
B. Scheiner, M. Kirstein, S. Popp, F. Hucke , S. Bota, N. Rohr-Udilova, T. Reiberger, Ch. Müller, M. Trauner , M. Peck-Radosavljevic , A. Vogel, W. Sieghart, M. Pinter. Association of platelet count and mean platelet volume with overall survival in patients with cirrhosis and unresectable hepatocellular carcinoma. Liver Cancer. 2019 May;8(3):203-217 
Philipp Schwabl, Ksenia Brusilovskaya, Paul Supper, David Bauer, Philipp Königshofer, Florian Riedl, Hubert Hayden, Claudia Fuchs, Judith Stift, Georg Oberhuber, Stefan Aschauer, Diana Bonderman, Thorsten Gnad, Alexander Pfeifer, Frank Uschner, Jonel Trebicka, Bruno Podesser, Nataliya Rohr-Udilova, Markus Peck-Radosavljevic, Michael Trauner, Thomas Reiberger. The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats. Sci Rep. 2018 Jun 19;8(1):9372 
Caruso S, Calatayud AL, Pilet J, La Bella T, Rekik S, Imbeaud S, Letouzé E, Meunier L, Bayard Q, Rohr-Udilova N, Péneau C, Grasl-Kraupp B, de Koning L, Ouine, B, Bioulac-Sage P, Couchy G, Calderaro J, Nault JC, Zucman-Rossi J, Rebouissou S. Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response. Gastroenterology. 2019 Sep;157(3):760-776.
Scheiner, B., Kirstein, M., Popp, S., Hucke, F., Bota, S., Rohr-Udilova, N., Reiberger, T., Müller, C., Trauner, M., Peck-Radosavljevic, M., Vogel, A., Sieghart, W., & Pinter, M. (2019). Association of Platelet Count and Mean Platelet Volume with Overall Survival in Patients with Cirrhosis and Unresectable Hepatocellular Carcinoma. Liver cancer, 8(3), 203–217.
Samadaei M, Pinter M, Senfter D, Madlener S, Rohr-Udilova N, Iwan D, Kamińska K, Wojaczyńska E, Wojaczyński J, Kochel A.et al. Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton. Molecules. 2020;25(10):2355.
Brusilovskaya K; Königshofer P; Lampach D; Szodl A; Supper P; Bauer D; Beer A; Stift J; Timelthaler G; Oberhuber G; Podesser B; Seif M; Zinober K; Rohr-Udilova N; Trauner M; Reiberger T; Schwabl P. Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct ligated rats. United European Gastroenterology Journal 2020 (in press) (DOI: 10.1177/2050640620944140/ ID: UEG-20-0196.R1).
Rohr-Udilova N., Tsuchiya K. Timelthaler G., Salzmann M., Meischl T., Wöran K., Stift J., Herac M., Schulte-Hermann R., Peck-Radosavljevic M, Sieghart W., Eferl R., Jensen-Jarolim E., Trauner M., Pinter M. Hepatology Communications 2021 (in press) DOI: 10.1002/hep4.1770

Nataliya Rohr-Udilova
Assoc. Prof.in Dr.in rer.nat. Nataliya Rohr-Udilova

Medical University of Vienna

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Letzte Aktualisierung: 08.04.2022